LOCUS       NM_138957               1514 bp    mRNA    linear   PRI 26-FEB-2014
DEFINITION  Homo sapiens mitogen-activated protein kinase 1 (MAPK1), transcript
            variant 2, mRNA.
ACCESSION   NM_138957
VERSION     NM_138957.3  GI:576796259
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1514)
  AUTHORS   Zhang F, Wang Z, Lu M, Yonekubo Y, Liang X, Zhang Y, Wu P, Zhou Y,
            Grinstein S, Hancock JF and Du G.
  TITLE     Temporal production of the signaling lipid phosphatidic acid by
            phospholipase D2 determines the output of extracellular
            signal-regulated kinase signaling in cancer cells
  JOURNAL   Mol. Cell. Biol. 34 (1), 84-95 (2014)
   PUBMED   24164897
  REMARK    GeneRIF: Findings indicate that phosphatidic acid (PA) production
            by PLD2 determines the output of ERK1/2 in cancer cell growth
            factor signaling.
REFERENCE   2  (bases 1 to 1514)
  AUTHORS   Yang CR, Liao WS, Wu YH, Murugan K, Chen C and Chao JI.
  TITLE     CR108, a novel vitamin K3 derivative induces apoptosis and breast
            tumor inhibition by reactive oxygen species and mitochondrial
            dysfunction
  JOURNAL   Toxicol. Appl. Pharmacol. 273 (3), 611-622 (2013)
   PUBMED   24128853
  REMARK    GeneRIF: CR108 is a novel vitamin K3 derivative that induces
            apoptosis and tumor inhibition by ROS production and mitochondrial
            dysfunction and associates with the phosphorylation of p38 MAP
            kinase and the inhibition of survivin in the human breast cancer.
REFERENCE   3  (bases 1 to 1514)
  AUTHORS   Yan J, Jiang N, Huang G, Tay JL, Lin B, Bi C, Koh GS, Li Z, Tan J,
            Chung TH, Lu Y, Ariffin H, Kham SK, Yeoh AE and Chng WJ.
  TITLE     Deregulated MIR335 that targets MAPK1 is implicated in poor outcome
            of paediatric acute lymphoblastic leukaemia
  JOURNAL   Br. J. Haematol. 163 (1), 93-103 (2013)
   PUBMED   23888996
  REMARK    GeneRIF: Deregulated MIR335 that targets MAPK1 is implicated in
            poor outcome of paediatric acute lymphoblastic leukaemia.
            Erratum:[Br J Haematol. 2013 Dec;163(5):688]
REFERENCE   4  (bases 1 to 1514)
  AUTHORS   Gu X, Yu JJ, Ilter D, Blenis N, Henske EP and Blenis J.
  TITLE     Integration of mTOR and estrogen-ERK2 signaling in
            lymphangioleiomyomatosis pathogenesis
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 110 (37), 14960-14965 (2013)
   PUBMED   23983265
  REMARK    GeneRIF: Integration of mTOR and estrogen-ERK2 signaling in
            lymphangioleiomyomatosis pathogenesis.
REFERENCE   5  (bases 1 to 1514)
  AUTHORS   Huang Q, Jin H, Xie Z, Wang M, Chen J and Zhou Y.
  TITLE     The role of the ERK1/2 signalling pathway in the pathogenesis of
            female stress urinary incontinence
  JOURNAL   J. Int. Med. Res. 41 (4), 1242-1251 (2013)
   PUBMED   23867452
  REMARK    GeneRIF: Female stress urinary incontinence is associated with
            reduced expression levels of phosphorylated ERK1 and ERK2 as
            compared to controls.
REFERENCE   6  (bases 1 to 1514)
  AUTHORS   Hu S, Xie Z, Onishi A, Yu X, Jiang L, Lin J, Rho HS, Woodard C,
            Wang H, Jeong JS, Long S, He X, Wade H, Blackshaw S, Qian J and Zhu
            H.
  TITLE     Profiling the human protein-DNA interactome reveals ERK2 as a
            transcriptional repressor of interferon signaling
  JOURNAL   Cell 139 (3), 610-622 (2009)
   PUBMED   19879846
  REMARK    GeneRIF: ERK2 acts as a transcriptional repressor for interferon
            gamma-induced genes.
REFERENCE   7  (bases 1 to 1514)
  AUTHORS   Goedert M, Cohen ES, Jakes R and Cohen P.
  TITLE     p42 MAP kinase phosphorylation sites in microtubule-associated
            protein tau are dephosphorylated by protein phosphatase 2A1.
            Implications for Alzheimer's disease [corrected]
  JOURNAL   FEBS Lett. 312 (1), 95-99 (1992)
   PUBMED   1330687
  REMARK    Erratum:[FEBS Lett 1992 Nov 23;313(2):203]
REFERENCE   8  (bases 1 to 1514)
  AUTHORS   Rossomando AJ, Wu J, Michel H, Shabanowitz J, Hunt DF, Weber MJ and
            Sturgill TW.
  TITLE     Identification of Tyr-185 as the site of tyrosine
            autophosphorylation of recombinant mitogen-activated protein kinase
            p42mapk
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 89 (13), 5779-5783 (1992)
   PUBMED   1378617
REFERENCE   9  (bases 1 to 1514)
  AUTHORS   Gonzalez FA, Raden DL, Rigby MR and Davis RJ.
  TITLE     Heterogeneous expression of four MAP kinase isoforms in human
            tissues
  JOURNAL   FEBS Lett. 304 (2-3), 170-178 (1992)
   PUBMED   1319925
REFERENCE   10 (bases 1 to 1514)
  AUTHORS   Owaki H, Makar R, Boulton TG, Cobb MH and Geppert TD.
  TITLE     Extracellular signal-regulated kinases in T cells: characterization
            of human ERK1 and ERK2 cDNAs
  JOURNAL   Biochem. Biophys. Res. Commun. 182 (3), 1416-1422 (1992)
   PUBMED   1540184
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC017832.1 and BQ774391.1.
            On Jan 29, 2014 this sequence version replaced gi:75709179.
            
            Summary: This gene encodes a member of the MAP kinase family. MAP
            kinases, also known as extracellular signal-regulated kinases
            (ERKs), act as an integration point for multiple biochemical
            signals, and are involved in a wide variety of cellular processes
            such as proliferation, differentiation, transcription regulation
            and development. The activation of this kinase requires its
            phosphorylation by upstream kinases. Upon activation, this kinase
            translocates to the nucleus of the stimulated cells, where it
            phosphorylates nuclear targets. One study also suggests that this
            protein acts as a transcriptional repressor independent of its
            kinase activity. The encoded protein has been identified as a
            moonlighting protein based on its ability to perform
            mechanistically distinct functions. Two alternatively spliced
            transcript variants encoding the same protein, but differing in the
            UTRs, have been reported for this gene. [provided by RefSeq, Jan
            2014].
            
            Transcript Variant: This variant (2) contains a different 3' UTR
            region, compared to variant 1. Both variants 1 and 2 encode the
            same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##RefSeq-Attributes-START##
            multifunctional gene product(s) :: PMID: 19879846
            ##RefSeq-Attributes-END##
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC017832.1 [ECO:0000332]
            RNAseq introns              :: mixed/partial sample support
                                           ERS025081, ERS025082 [ECO:0000350]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1487              BC017832.1         1-1487
            1488-1514           BQ774391.1         1-27                c
FEATURES             Location/Qualifiers
     source          1..1514
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="22"
                     /map="22q11.21"
     gene            1..1514
                     /gene="MAPK1"
                     /gene_synonym="ERK; ERK-2; ERK2; ERT1; MAPK2; p38; p40;
                     p41; p41mapk; p42-MAPK; P42MAPK; PRKM1; PRKM2"
                     /note="mitogen-activated protein kinase 1"
                     /db_xref="GeneID:5594"
                     /db_xref="HGNC:6871"
                     /db_xref="HPRD:01496"
                     /db_xref="MIM:176948"
     exon            1..359
                     /gene="MAPK1"
                     /gene_synonym="ERK; ERK-2; ERK2; ERT1; MAPK2; p38; p40;
                     p41; p41mapk; p42-MAPK; P42MAPK; PRKM1; PRKM2"
                     /inference="alignment:Splign:1.39.8"
     misc_feature    178..180
                     /gene="MAPK1"
                     /gene_synonym="ERK; ERK-2; ERK2; ERT1; MAPK2; p38; p40;
                     p41; p41mapk; p42-MAPK; P42MAPK; PRKM1; PRKM2"
                     /note="upstream in-frame stop codon"
     CDS             241..1323
                     /gene="MAPK1"
                     /gene_synonym="ERK; ERK-2; ERK2; ERT1; MAPK2; p38; p40;
                     p41; p41mapk; p42-MAPK; P42MAPK; PRKM1; PRKM2"
                     /EC_number="2.7.11.24"
                     /note="protein tyrosine kinase ERK2; extracellular
                     signal-regulated kinase 2; mitogen-activated protein
                     kinase 2; MAPK 2; MAP kinase 1; MAP kinase 2; MAP kinase
                     isoform p42"
                     /codon_start=1
                     /product="mitogen-activated protein kinase 1"
                     /protein_id="NP_620407.1"
                     /db_xref="GI:20986531"
                     /db_xref="CCDS:CCDS13795.1"
                     /db_xref="GeneID:5594"
                     /db_xref="HGNC:6871"
                     /db_xref="HPRD:01496"
                     /db_xref="MIM:176948"
                     /translation="MAAAAAAGAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYD
                     NVNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVY
                     IVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTT
                     CDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCIL
                     AEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWN
                     RLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDME
                     LDDLPKEKLKELIFEETARFQPGYRS"
     misc_feature    244..246
                     /gene="MAPK1"
                     /gene_synonym="ERK; ERK-2; ERK2; ERT1; MAPK2; p38; p40;
                     p41; p41mapk; p42-MAPK; P42MAPK; PRKM1; PRKM2"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="N-acetylalanine; propagated from
                     UniProtKB/Swiss-Prot (P28482.3); acetylation site"
     misc_feature    325..327
                     /gene="MAPK1"
                     /gene_synonym="ERK; ERK-2; ERK2; ERT1; MAPK2; p38; p40;
                     p41; p41mapk; p42-MAPK; P42MAPK; PRKM1; PRKM2"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine, by SGK1; propagated from
                     UniProtKB/Swiss-Prot (P28482.3); phosphorylation site"
     misc_feature    553..564
                     /gene="MAPK1"
                     /gene_synonym="ERK; ERK-2; ERK2; ERT1; MAPK2; p38; p40;
                     p41; p41mapk; p42-MAPK; P42MAPK; PRKM1; PRKM2"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (P28482.3);
                     Region: Inhibitor-binding"
     misc_feature    697..702
                     /gene="MAPK1"
                     /gene_synonym="ERK; ERK-2; ERK2; ERT1; MAPK2; p38; p40;
                     p41; p41mapk; p42-MAPK; P42MAPK; PRKM1; PRKM2"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (P28482.3);
                     Region: Inhibitor-binding"
     misc_feature    793..801
                     /gene="MAPK1"
                     /gene_synonym="ERK; ERK-2; ERK2; ERT1; MAPK2; p38; p40;
                     p41; p41mapk; p42-MAPK; P42MAPK; PRKM1; PRKM2"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (P28482.3);
                     Region: TXY"
     misc_feature    793..795
                     /gene="MAPK1"
                     /gene_synonym="ERK; ERK-2; ERK2; ERT1; MAPK2; p38; p40;
                     p41; p41mapk; p42-MAPK; P42MAPK; PRKM1; PRKM2"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphothreonine, by MAP2K1 and MAP2K2; propagated
                     from UniProtKB/Swiss-Prot (P28482.3); phosphorylation
                     site"
     misc_feature    799..801
                     /gene="MAPK1"
                     /gene_synonym="ERK; ERK-2; ERK2; ERT1; MAPK2; p38; p40;
                     p41; p41mapk; p42-MAPK; P42MAPK; PRKM1; PRKM2"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphotyrosine, by MAP2K1 and MAP2K2; propagated
                     from UniProtKB/Swiss-Prot (P28482.3); phosphorylation
                     site"
     misc_feature    808..810
                     /gene="MAPK1"
                     /gene_synonym="ERK; ERK-2; ERK2; ERT1; MAPK2; p38; p40;
                     p41; p41mapk; p42-MAPK; P42MAPK; PRKM1; PRKM2"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphothreonine, by autocatalysis; propagated from
                     UniProtKB/Swiss-Prot (P28482.3); phosphorylation site"
     misc_feature    976..978
                     /gene="MAPK1"
                     /gene_synonym="ERK; ERK-2; ERK2; ERT1; MAPK2; p38; p40;
                     p41; p41mapk; p42-MAPK; P42MAPK; PRKM1; PRKM2"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
                     (P28482.3); phosphorylation site"
     misc_feature    982..984
                     /gene="MAPK1"
                     /gene_synonym="ERK; ERK-2; ERK2; ERT1; MAPK2; p38; p40;
                     p41; p41mapk; p42-MAPK; P42MAPK; PRKM1; PRKM2"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
                     (P28482.3); phosphorylation site"
     misc_feature    1090..1092
                     /gene="MAPK1"
                     /gene_synonym="ERK; ERK-2; ERK2; ERT1; MAPK2; p38; p40;
                     p41; p41mapk; p42-MAPK; P42MAPK; PRKM1; PRKM2"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
                     (P28482.3); phosphorylation site"
     misc_feature    1192..1206
                     /gene="MAPK1"
                     /gene_synonym="ERK; ERK-2; ERK2; ERT1; MAPK2; p38; p40;
                     p41; p41mapk; p42-MAPK; P42MAPK; PRKM1; PRKM2"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (P28482.3);
                     Region: Cytoplasmic retention motif"
     misc_feature    1219..1239
                     /gene="MAPK1"
                     /gene_synonym="ERK; ERK-2; ERK2; ERT1; MAPK2; p38; p40;
                     p41; p41mapk; p42-MAPK; P42MAPK; PRKM1; PRKM2"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (P28482.3);
                     Region: Nuclear translocation motif"
     exon            360..542
                     /gene="MAPK1"
                     /gene_synonym="ERK; ERK-2; ERK2; ERT1; MAPK2; p38; p40;
                     p41; p41mapk; p42-MAPK; P42MAPK; PRKM1; PRKM2"
                     /inference="alignment:Splign:1.39.8"
     exon            543..732
                     /gene="MAPK1"
                     /gene_synonym="ERK; ERK-2; ERK2; ERT1; MAPK2; p38; p40;
                     p41; p41mapk; p42-MAPK; P42MAPK; PRKM1; PRKM2"
                     /inference="alignment:Splign:1.39.8"
     exon            733..849
                     /gene="MAPK1"
                     /gene_synonym="ERK; ERK-2; ERK2; ERT1; MAPK2; p38; p40;
                     p41; p41mapk; p42-MAPK; P42MAPK; PRKM1; PRKM2"
                     /inference="alignment:Splign:1.39.8"
     exon            850..964
                     /gene="MAPK1"
                     /gene_synonym="ERK; ERK-2; ERK2; ERT1; MAPK2; p38; p40;
                     p41; p41mapk; p42-MAPK; P42MAPK; PRKM1; PRKM2"
                     /inference="alignment:Splign:1.39.8"
     exon            965..1096
                     /gene="MAPK1"
                     /gene_synonym="ERK; ERK-2; ERK2; ERT1; MAPK2; p38; p40;
                     p41; p41mapk; p42-MAPK; P42MAPK; PRKM1; PRKM2"
                     /inference="alignment:Splign:1.39.8"
     exon            1097..1206
                     /gene="MAPK1"
                     /gene_synonym="ERK; ERK-2; ERK2; ERT1; MAPK2; p38; p40;
                     p41; p41mapk; p42-MAPK; P42MAPK; PRKM1; PRKM2"
                     /inference="alignment:Splign:1.39.8"
     exon            1207..1497
                     /gene="MAPK1"
                     /gene_synonym="ERK; ERK-2; ERK2; ERT1; MAPK2; p38; p40;
                     p41; p41mapk; p42-MAPK; P42MAPK; PRKM1; PRKM2"
                     /inference="alignment:Splign:1.39.8"
     polyA_signal    1469..1474
                     /gene="MAPK1"
                     /gene_synonym="ERK; ERK-2; ERK2; ERT1; MAPK2; p38; p40;
                     p41; p41mapk; p42-MAPK; P42MAPK; PRKM1; PRKM2"
     polyA_site      1497
                     /gene="MAPK1"
                     /gene_synonym="ERK; ERK-2; ERK2; ERT1; MAPK2; p38; p40;
                     p41; p41mapk; p42-MAPK; P42MAPK; PRKM1; PRKM2"
ORIGIN      
        1 gcccctccct ccgcccgccc gccggcccgc ccgtcagtct ggcaggcagg caggcaatcg
       61 gtccgagtgg ctgtcggctc ttcagctctc ccgctcggcg tcttccttcc tcctcccggt
      121 cagcgtcggc ggctgcaccg gcggcggcgc agtccctgcg ggaggggcga caagagctga
      181 gcggcggccg ccgagcgtcg agctcagcgc ggcggaggcg gcggcggccc ggcagccaac
      241 atggcggcgg cggcggcggc gggcgcgggc ccggagatgg tccgcgggca ggtgttcgac
      301 gtggggccgc gctacaccaa cctctcgtac atcggcgagg gcgcctacgg catggtgtgc
      361 tctgcttatg ataatgtcaa caaagttcga gtagctatca agaaaatcag cccctttgag
      421 caccagacct actgccagag aaccctgagg gagataaaaa tcttactgcg cttcagacat
      481 gagaacatca ttggaatcaa tgacattatt cgagcaccaa ccatcgagca aatgaaagat
      541 gtatatatag tacaggacct catggaaaca gatctttaca agctcttgaa gacacaacac
      601 ctcagcaatg accatatctg ctattttctc taccagatcc tcagagggtt aaaatatatc
      661 cattcagcta acgttctgca ccgtgacctc aagccttcca acctgctgct caacaccacc
      721 tgtgatctca agatctgtga ctttggcctg gcccgtgttg cagatccaga ccatgatcac
      781 acagggttcc tgacagaata tgtggccaca cgttggtaca gggctccaga aattatgttg
      841 aattccaagg gctacaccaa gtccattgat atttggtctg taggctgcat tctggcagaa
      901 atgctttcta acaggcccat ctttccaggg aagcattatc ttgaccagct gaaccacatt
      961 ttgggtattc ttggatcccc atcacaagaa gacctgaatt gtataataaa tttaaaagct
     1021 aggaactatt tgctttctct tccacacaaa aataaggtgc catggaacag gctgttccca
     1081 aatgctgact ccaaagctct ggacttattg gacaaaatgt tgacattcaa cccacacaag
     1141 aggattgaag tagaacaggc tctggcccac ccatatctgg agcagtatta cgacccgagt
     1201 gacgagccca tcgccgaagc accattcaag ttcgacatgg aattggatga cttgcctaag
     1261 gaaaagctca aagaactaat ttttgaagag actgctagat tccagccagg atacagatct
     1321 taaatttgtc aggtacctgg agtttaatac agtgagctct agcaagggag gcgctgcctt
     1381 ttgtttctag aatattatgt tcctcaaggt ccattatttt gtattctttt ccaagctcct
     1441 tattggaagg tattttttta aatttagaat taaaaattat ttagaaagtt acatataaaa
     1501 aaaaaaaaaa aaaa
//

